Genetic Testing in Brugada Syndrome
نویسندگان
چکیده
منابع مشابه
Genetic testing in Brugada syndrome.
Brugada syndrome (BrS) is a hereditary arrhythmic disorder associated with a right ventricular conduction delay and ST-segment elevation in the right precordial leads and syncope and sudden death due to ventricular fibrillation (1). The type 1 Brugada electrocardiographic ECG pattern (coved ST-segment elevations in leads V1 to V3) is a ynamic finding that may be present at baseline or may ecome...
متن کاملGenetic Basis of Brugada Syndrome
Brugada syndrome is a rare cardiac disorder described as a clinical entity in 1992. It is characterized by typical electrocardiographic alteration in a structurally normal heart, and associated with a high risk of sudden cardiac death. Brugada syndrome affects mainly young adult males and patients can present a wide range of symptoms or even remain asymptomatic. The first genetic basis responsi...
متن کاملThe genetic component of Brugada syndrome
Brugada syndrome (BrS) is a clinical entity first described in 1992. BrS is characterized by ST-segment elevations in the right precordial leads and susceptibility to ventricular arrhythmias and sudden cardiac death. It affects young subjects, predominantly males, with structurally normal hearts. The prevalence varies with ethnicity ranging from 1:2,000 to 1:100,000 in different parts of the wo...
متن کاملComplex genetic background in a large family with Brugada syndrome
The Brugada syndrome (BrS) is an inherited arrhythmia characterized by ST-segment elevation in V1-V3 leads and negative T wave on standard ECG. BrS patients are at risk of sudden cardiac death (SCD) due to ventricular tachyarrhythmia. At least 17 genes have been proposed to be linked to BrS, although recent findings suggested a polygenic background. Mutations in SCN5A, the gene coding for the c...
متن کاملBrugada syndrome.
Brugada syndrome is a rare cardiac arrhythmia characterized by electrocardiographic right bundle branch block and persistent ST-segment elevation in the right precordial leads. It is associated with ventricular fibrillation and a high risk for sudden cardiac death, predominantly in younger males with structurally normal hearts. Patients can remain asymptomatic, and electrocardiographic patterns...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2012
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2012.05.011